Selected Publications
Pubmed search Dr. A. K. Stewart's Laboratory's publications.
  1. Chang H, Stewart AK, Qi XY, Li ZH, Yi QL, Trudel S. (2005) Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma. Blood. 2005 Mar 10; [Epub ahead of print] PMID: 15761022.

  2. Claudio JO, Stewart AK. (2005) Advances in myeloma genetics and prospects for pharmacogenomic testing in multiple myeloma. Am J Pharmacogenomics. 5(1):35-43.

  3. Chang H, Qi C, Yi QL, Reece D, Stewart AK. (2005) p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation. Blood. 105(1):358-60.

  4. Claudio JO, Zhu YX, Stewart AK. (2005) Samsn1. AfCS-Nature Molecule Pages. doi:10.1038/mp.a003685.01.

  5. Stewart AK, Chen CI, Howson-Jan K, White D, Roy J, Kovacs MJ, Shustik C, Sadura A, Shepherd L, Ding K, Meyer RM, Belch AR. (2004) Results of a multicenter randomized phase II trial of thalidomide and prednisone maintenance therapy for multiple myeloma after autologous stem cell transplant. Clin Cancer Res. 10(24):8170-8176.

  6. Trudel S, Li ZH, Wei E, Wiesmann M, Chang H, Chen C, Reece D, Heise C, Stewart AK. (2004) CHIR-258, a novel, multi-targeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood. 2004 Dec 14; [Epub ahead of print] PMID: 15598814.

  7. Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, Bali M, McGlade CJ, Claudio JO, Stewart AK. (2004) The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med. 200(6):737-747.

  8. Claudio JO, Masih-Khan E, Stewart AK. (2004) Insights from the gene expression profiling of multiple myeloma. Curr Hematol Rep. 3(1):67-73.

  9. Chang H, Li D, Zhuang L, Nie E, Bouman D, Stewart AK, Chun K. (2004) Detection of chromosome 13q deletions and IgH translocations in patients with multiple myeloma by FISH: comparison with karyotype analysis. Leuk Lymphoma. 45:965-969.

  10. Trieu Y, Wen XY, Skinnider BF, Bray MR, Li Z, Claudio JO, Masih-Khan E, Zhu YX, Trudel S, McCart JA, Mak TW, Stewart AK. (2004) Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo. Cancer Res. 64(9):3271-3275.

  11. Fonseca R, Barlogie B, Bataille R, Bastard C, Bergsagel PL, Chesi M, Davies FE, Drach J, Greipp PR, Kirsch IR, Kuehl WM, Hernandez JM, Minvielle S, Pilarski LM, Shaughnessy JD Jr, Stewart AK, Avet-Loiseau H. (2004) Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res. 64(4):1546-58.

  12. Paterson JL, Li Z, Wen XY, Masih-Khan E, Chang H, Pollett JB, Trudel S, Stewart AK. (2004) Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br J Haematol. 124:595-603.

  13. Li ZH, Wen XY, Mandelbaum S, Falcioni N, Hawley TS, Hawley RG, Stewart AK. (2003) Improved therapeutic outcome following combination immunogene vaccination therapy in murine myeloma. Leuk Lymphoma. 44:1775-84.

  14. Pollett JB, Trudel S, Stern D, Li ZH, Stewart AK. (2002) Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance. Blood. 100:3819-3821.

  15. Claudio JO, Masih-Khan E, Tang H, Goncalves J, Voralia M, Li ZH, Nadeem V, Cukerman E, Francisco-Pabalan O, Liew CC, Woodgett JR, and Stewart, A.K. (2002) A molecular compendium of genes expressed in multiple myeloma. Blood. 100:2175 -2186.

  16. Claudio, J.O. Zhu, Y.X., Benn, S.J., Shukla, A.H.McGlade, C.J., Falcioni, N. and Stewart, A.K. (2001) HACS1 encodes a novel SH3-SAM adaptor protein differentially expressed in normal and malignant hematopoietic cells. Oncogene.20:2373-5377.

  17. Zhu, Y.X., Li, Z.H., Stewart, A.K. (2001)Antigenic open reading frames from HHV-8 are present at similar frequency in multiple myeloma patients and normal individuals and are unmutated. Leuk Lymphoma 43:369-375.

  18. Wen XY, Mandelbaum S, Li ZH, Hitt M, Graham FL, Hawley TS, Hawley RG, Stewart AK. (2001) Tricistronic viral vectors co-expressing interleukin-12 (1L-12) and CD80 (B7-1) for the immunotherapy of cancer. Cancer Gene Ther. 8:361-370.

  19. Li Z, Zhu YX, Plowright EE, Bergsagel PL, Chesi M, Patterson B, Hawley TS, Hawley RG, Stewart AK. The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells. Blood. 2001 Apr 15;97(8):2413-9.

  20. Chen CI, Abraham R, Tsang R, Crump M, Keating A, Stewart AK. Radiation-associated pneumonitis following autologous stem cell transplantation: predictive factors, disease characteristics and treatment outcomes. Bone Marrow Transplant. 2001 Jan;27(2):177-82.

  21. Wen XY, Bai Y, Stewart AK. Adenovirus-mediated human endostatin gene delivery demonstrates strain-specific antitumor activity and acute dose-dependent toxicity in mice. Hum Gene Ther. 2001 Mar 1;12(4):347-58.

  22. Omori F, Juopperi T, Chan CK, Chang YN, Phipps S, Nanji S, Zhao Y, Stewart AK, Dube ID. Retroviral-mediated transfer and expression of the multidrug resistance protein 1 gene (MRP1) protect human hematopoietic cells from antineoplastic drugs. J Hematother Stem Cell Res. 1999 Oct;8(5):503-14.

  23. Stewart AK, Schuh AC. White cells 2: impact of understanding the molecular basis of haematological malignant disorders on clinical practice. Lancet. 2000 Apr 22;355(9213):1447-53. Review.

  24. Dilworth D, Liu L, Stewart AK, Berenson JR, Lassam N, Hogg D. Germline CDKN2A mutation implicated in predisposition to multiple myeloma. Blood. 2000 Mar 1;95(5):1869-71.

  25. Plowright EE, Li Z, Bergsagel PL, Chesi M, Barber DL, Branch DR, Hawley RG, Stewart AK. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood. 2000 Feb 1;95(3):992-8.

  26. Abraham R, Chen C, Tsang R, Simpson D, Murray C, Davidson M, Meharchand J, Sutton DM, Crump RM, Keating A, Stewart AK. Intensification of the stem cell transplant induction regimen results in increased treatment-related mortality without improved outcome in multiple myeloma. Bone Marrow Transplant. 1999 Dec;24(12):1291-7.

  27. Howard DS, Rizzierri DA, Grimes B, Upchurch D, Phillips GL, Stewart AK, Yannelli JR, Jordan CT. Genetic manipulation of primitive leukemic and normal hematopoietic cells using a novel method of adenovirus-mediated gene transfer. Leukemia. 1999 Oct;13(10):1608-16.

  28. Stewart AK, Sutherland DR, Nanji S, Zhao Y, Lutzko C, Nayar R, Peck B, Ruedy C, McGarrity G, Tisdale J, Dube ID. Engraftment of gene-marked hematopoietic progenitors in myeloma patients after transplant of autologous long-term marrow cultures. Hum Gene Ther. 1999 Aug 10;10(12):1953-64.

  29. Goss P, Stewart AK, Couture F, Klasa R, Gluck S, Kaizer L, Burkes R, Charpentier D, Palmer M, Tye L, Dulude H. Combined results of two phase II studies of Taxol (paclitaxel) in patients with relapsed or refractory lymphomas. Leuk Lymphoma. 1999 Jul;34(3-4):295-304.

  30. Lutzko C, Dube ID, Stewart AK. Recent progress in gene transfer into hematopoietic stem cells. Crit Rev Oncol Hematol. 1999 Apr;30(2):143-58. Review.

  31. Stewart AK, Lassam NJ, Quirt IC, Bailey DJ, Rotstein LE, Krajden M, Dessureault S, Gallinger S, Cappe D, Wan Y, Addison CL, Moen RC, Gauldie J, Graham FL. Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial. Gene Ther. 1999 Mar;6(3):350-63.

  32. Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG. Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13. Genomics. 1999 Jul 1;59(1):85-9.

  33. Wen XY, Stewart AK, Sooknanan RR, Henderson G, Hawley TS, Reimold AM, Glimcher LH, Baumann H, Malek LT, Hawley RG. Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells. Int J Oncol. 1999 Jul;15(1):173-8.

  34. Vescio R, Schiller G, Stewart AK, Ballester O, Noga S, Rugo H, Freytes C, Stadtmauer E, Tarantolo S, Sahebi F, Stiff P, Meharchard J, Schlossman R, Brown R, Tully H, Benyunes M, Jacobs C, Berenson R, DiPersio J, Anderson K, Berenson J. Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma. Blood. 1999 Mar 15;93(6):1858-68.

  35. Omori F, Lutzko C, Abrams-Ogg A, Lau K, Gartley C, Dobson H, Nanji S, Ruedy C, Singaraja R, Li L, Stewart AK, Kruth S, Dube ID. Adoptive transfer of genetically modified human hematopoietic stem cells into preimmune canine fetuses. Exp Hematol. 1999 Feb;27(2):242-9.

  36. Tisdale JF, Stewart AK, Dickstein B, Little RF, Dube I, Cappe D, Dunbar CE, Brown KE. Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected. Blood. 1998 Oct 15;92(8):2681-7.

  37. Catzavelos C, Ruedy C, Stewart AK, Dube I. A novel method for the direct quantification of gene transfer into cells using PCR in situ. Gene Ther. 1998 Jun;5(6):755-60.

  38. Schimmer AD, Stewart AK, Keating A, MacKinnon J, Crump M, Sutton DM, Shepherd FA, Meharchand J. Safety of therapeutic anticoagulation in patients with multiple myeloma receiving autologous stem cell transplantation. Bone Marrow Transplant. 1998 Sep;22(5):491-4.

  39. Claudio JO, Liew CC, Dempsey AA, Cukerman E, Stewart AK, Na E, Atkins HL, Iscove NN, Hawley RG. Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy. Genomics. 1998 May 15;50(1):44-52.