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Publications 2007 | 2006 | 2005 | 2004 | 2003 | 2002 |
2001 | 2000 | 1999
| Pre-1999
Article
titles are linked to the PubMed database abstracts
The
article's journal title is linked to the journal's online access
(if available)
2007
Hedley D, Schwock J, Pham NA, Cao M.
Efficacy of Hsp90 inhibition for induction of apoptosis and
inhibition of growth in cervical carcinoma cells in vitro and in
vivo. Cancer Chemotherapy and Pharmacology, (in press).
Bristow RG, Ozcelik H, Jalali F,
Chan N, Vesprini D. Homologous recombination and prostate
cancer: a model for novel DNA repair targets and therapies.
Radiotherapy and Oncology, (in press).
Chan N, Milosevic M, Bristow RG.
Tumor hypoxia, DNA repair and prostate cancer progression: new
targets and new therapies. Future Oncology, (in press).
Schwock J, Ho JC, Luther E, Hedley
DW, Geddie WR. Detection and measurement of phosphorylated
signaling proteins in solid tumor fine-needle biopsies by
laser-scanning cytometry. Diagnostic Molecular Pathology, (in
press).
Pham NA, Morrison A, Schwock J,
Aviel-Ronen S, Iakovlev V, Tsao MS, Ho J, Hedley DW.
Quantitative image analysis of immunohistochemical stains using
a CMYK color model.
Diagn Pathol, 2:8, 2007.
Birle DC, Hedley DW.
Suppression of the hypoxia-inducible factor-1 response in
cervical carcinoma xenografts by proteasome inhibitors.
Cancer Res, 67(4)1735-1743, 2007.
Haider MA, Sitartchouk I, Roberts TP,
Fyles A, Hashmi AT, Milosevic M.
Correlations between dynamic contrast-enhanced magnetic
resonance imaging-derived measures of tumor microvasculature and
interstitial fluid pressure in patients with cervical cancer.
J Magn Reson Imaging, 25(1)153-159, 2007.
Herrera FG, Chan P, Doll C,
Milosevic M, Oza A, Syed A, Pintilie M, Levin W, Manchul L,
Fyles A.
A prospective phase I-II trial of the cyclooxygenase-2 inhibitor
celecoxib in patients with carcinoma of the cervix with
biomarker assessment of the tumor microenvironment.
Int J
Radiat Oncol Biol Phys, 67(1)97-103, 2007.
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2006
Bachtiary B, Boutros PC, Pintilie M,
Shi W, Bastianutto C, Li JH, Schwock J, Zhang W, Penn LZ,
Jurisica I, Fyles A, Liu FF.
Gene expression profiling in cervical cancer: an exploration of
intratumor heterogeneity.
Clin Cancer Res, 12(19)5632-5640,
2006.
Birle DC, Hedley DW.
Signaling interactions of rapamycin combined with erlotinib in
cervical carcinoma xenografts.
Mol Cancer Ther,
5(10)2494-2502, 2006.
Fyles A, Milosevic M, Pintilie M,
Syed A, Levin W, Manchul L, Hill RP.
Long-term performance of interstitial fluid pressure and hypoxia
as prognostic factors in cervix cancer.
Radiother Oncol,
80(2):132-137, 2006.
Skliarenko JV, Lunt SJ, Gordon ML,
Vitkin A, Milosevic M, Hill RP.
Effects of the vascular disrupting agent ZD6126 on the
interstitial fluid pressure and cell survival in tumors.
Cancer Res, 66(4):2074-2080, 2006.
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2005
Haider MA, Milosevic M, Fyles A,
Sitartchouk I, Yeung I, Henderson E, Lockwood G, Lee TY, Roberts
TP.
Assessment of the tumour microenvironment in cervix cancer using
dynamic contrast enhanced CT, interstitial fluid pressure and
oxygen measurements.
Int J Radiat Oncol Biol Phys,
62(4):1100-1107, 2005.
Meng AX, Jalali F, Cuddihy A, Chan
N, Bindra RS, Glazer PM, Bristow RG.
Hypoxia down-regulates DNA double strand break repair gene
expression in prostate cancer cells.
Radiother Oncol,
76(2):168-176, 2005.
Schwock J, Geddie WR, Hedley DW.
Analysis of hypoxia-inducible factor-1alpha accumulation and
cell cycle in geldanamycin-treated human cervical carcinoma
cells by laser scanning cytometry.
Cytometry A, 68(2):59-70,
2005.
Hedley DW, Nicklee T, Moreno-Merlo F, Pintilie M, Fyles A, Milosevic M, Hill
RP. Relations between non-protein sulfydryl levels in the nucleus and
cytoplasm,
tumor oxygenation, and clinical outcome of patients with uterine
cervical
carcinoma. Int J Radiat Oncol Biol
Phys, 61(1):137-44, 2005.
Lolkema MP, Gervais ML, Snijckers CM, Hill RP, Giles RH, Voest EE, Ohh M.
Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of
the acidic domain. J Biol
Chem, Apr 11, 2005.
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2004
Cairns RA, Hill RP. A fluorescent orthotopic model of metastatic cervical carcinoma.
Clin Exp Metastasis, 21(3):275-81, 2004.
Hedley D, Pintilie M, Woo J,
Nicklee T, Morrison A, Birle D, Fyles A,
Milosevic M, Hill R. Up-regulation of the redox mediators thioredoxin and
apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive
cervical carcinomas, mapped using multispectral, wide-field fluorescence image
analysis. Am J
Pathol, 164(2):557-65, 2004.
Parker C, Milosevic M, Toi A, Sweet J, Panzarella T, Bristow R, Catton C,
Catton P, Crook J, Gospodarowicz M, McLean M, Warde P, Hill RP. Polarographic electrode study of tumor oxygenation in clinically localized
prostate cancer. Int J Radiat Oncol Biol
Phys, 58(3):750-7,
2004.
Cairns RA, Hill RP. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic
murine model of human cervical carcinoma. Cancer
Res,
64(6):2054-61, 2004.
Stickle NH, Chung J, Klco JM, Hill RP, Kaelin WG
Jr, Ohh M. pVHL modification by NEDD8 is required for fibronectin matrix assembly and
suppression of tumor development. Mol Cell
Biol,
24(8):3251-61, 2004.
Kalliomaki T, Hill RP. Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic
potential of two murine cell lines. Br J
Cancer,
90(9):1842-9, 2004.
Zhang L, Hill RP. Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and
increasing resistance to apoptosis. Cancer
Res,
64(12):4180-9, 2004.
Maseide K, Kandel RA, Bell RS, Catton
CN, O'Sullivan B, Wunder JS, Pintilie M, Hedley D, Hill RP. Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma.
Clin Cancer Res, 10(13):4464-71, 2004.
Ruoso P, Hedley DW. Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular
cysteine levels in cervical carcinoma. Cancer Chemother
Pharmacol.
54(1):49-56, 2004.
Bindra RS, Schaffer PJ, Meng A, Woo J, Maseide K, Roth ME, Lizardi P, Hedley
DW, Bristow RG, Glazer PM. Down-regulation of Rad51 and decreased homologous recombination in hypoxic
cancer cells. Mol Cell
Biol, 24(19):8504-18, 2004.
Khosravani H, Chugh B, Milosevic MF, Norwich KH.
Time response of interstitial fluid pressure measurements in cervix cancer.
Microvasc Res, 68(1):63-70, 2004.
Milosevic M, Fyles A, Hedley D, Hill R.
The human tumor
microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure.
Semin Radiat Oncol, 14(3):249-58, 2004.
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2003
Doll CM, Milosevic M, Pintilie M, Hill RP, Fyles AW.
Estimating hypoxic status in human tumors: A simulation using Eppendorf oxygen probe data in cervical cancer patients.
Int. J. Radiat. Oncol. Biol. Phys. 55(5):1239-1246, 2003.
Subarsky P and Hill RP. Metastasis and the tumor microenvironment.
Clin Exper Metastasis, 20(3):237-250, 2003.
Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view.
Curr Mol Med, 3(7):659-71, 2003.
Tsang RW, Juvet S, Pintilie M, Hill RP, Wong CS, Milosevic M, Chapman W,
Levin W, Manchul LA, Fyles AW. Pretreatment proliferation parameters do not add predictive power to clinical
factors in cervical cancer treated with definitive radiation therapy.
Clin Cancer Res, 9(12):4387-95, 2003.
Hedley D, Pintilie M, Woo J, Morrison A, Birle D, Fyles A, Milosevic M, Hill
R. Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with
uterine cervical carcinomas. Clin Cancer
Res, 9(15):5666-74,
2003.
Henderson E, Milosevic M, Haider M, Yeung
IW. Functional CT imaging of prostate cancer.
Phys Med Biol,
48(18):3085-100, 2003.
Hill RP, Fyles W, Milosevic M,
Pintilie M, Tsang RW. Is there a relationship between repopulation and hypoxia/reoxygenation?
Results from human carcinoma of the cervix. Int J Radiat
Biol, 79(7):487-94, 2003.
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2002
Haugland,H.K., Vukovic,V., Pintillie,M., Fyles,A.W., Milosevic,M., Hill,R.P., and Hedley,D.W.
Expression of hypoxia-inducible factor
1a in cervical carcinomas: correlation with tumor oxygenation and clinical outcome.
Int J Radiat Oncol Biol Phys 53: 854-861, 2002.
Vukovic,V., Nicklee,T., and Hedley,D.W.
Multiparameter fluorescence mapping of non-protein sulfydryl status in relation to blood vessels and hypoxia in cervical carcinoma xenografts.
Int J Radiat Oncol Biol Phys 52:837-43, 2002.
Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill R.
Tumor hypoxia is an independent predictor of outcome in patients with node negative cervix cancer.
J Clin Oncol, 20: 680-687, 2002.
Fyles A, Voduc D, Syed A, Milosevic M, Pintilie M, Hill R.
The effect of smoking on tumour oxygenation and treatment outcome in cervical cancer. Clin. Oncol. 14: 443-446, 2002.
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2001
Pitson G, Fyles A, Milosevic M, Wylie J, Pintilie M, Hill R.
Tumor size and oxygenation are independent predictors of nodal disease in patients with cervix cancer.
International Journal of Radiation Oncol. Biol. Phys. 51: 699-703, 2001.
Milosevic M, Quirt I, Levin W, Fyles A, Chapman W.
Intra-tumoral sickling in a patient with sickle trait and cervix cancer: implications for tumor oxygenation and outcome following therapy.
Gyn Oncol, 83: 428-431, 2001.
Milosevic M, Fyles A, Pintilie M, Levin W, Manchul L, Hill R
Interstitial Fluid Pressure Predicts Survival in Patients with Cervix Cancer Independent of Clinical Prognostic Factors and Tumor Oxygen Measurements.
Cancer Res, 61:6400-5, 2001.
Milosevic M, Fyles A, Hill R. Interstitial fluid pressure in cervical cancer: guide to targeted therapy.
Am J Clin Oncol. 24:516-21, 2001.
De Jaeger, K., Kavanagh, M-C., Hill, RP.
Relationship of hypoxia to metastatic ability in rodent tumours.
Brit J Cancer, 84: 1280-1285, 2001.
Cairns, RA, Kalliomaki T., Hill RP. Acute (cyclic) Hypoxia Enhances Spontaneous Metastasis of Murine Tumors.
Cancer Res 61 (24): 8903-8, 2001.
Hill RP. Tumour Metastasis Models. In: Cancer Handbook. Eds Nicolson G, Haier J, Nature Publishing Group, London 2001.
Hill RP, Cairns R, De Jaeger K, Jang A.
pH, Hypoxia and Metastasis. In: Causes and Consequences of Acidic pH in tumours Novartis Symposium 240. Wiley, London 2001.
Constantinou, P., Vukovic, V., Haugland, H. K., Nicklee, T., Hedley, D. W., and Wilson, B. C.
Imaging of whole tumor cut sections using a novel scanning beam confocal fluorescence MACROscope((R)).
J Biomed Optics, 6: 326-331, 2001.
Vukovic, V., Haugland, H.K., Nicklee, T., Morrison, A.J., and Hedley, D.W.
Hypoxia inducible
factor-1a is an intrinsic marker for hypoxia in cervical cancer xenografts.
Cancer Res 61:7394-7398, 2001.
Vukovic, V., Nicklee,T., and Hedley,D.W.
Differential effects of buthionine sulphoximine in hypoxic and
non-hypoxic regions of human cervical carcinoma xenografts.
Radiother Oncol
60(1):69-73, 2001.
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2000
Vukovic V, Pheng SR, Stewart A, Vik
CH, Hedley DW. Protection from radiation-induced DNA single strand breaks by induction of nuclear metallothionein.
International Journal of Radiation Biology, 76:757-762,
2000.
Vukovic,V., Nicklee,T., and Hedley,D.W.
Microregional heterogeneity of non-protein thiols in cervical carcinomas assessed by combined use of HPLC and fluorescence image analysis.
Clin Cancer
Res, 6:1826-1832, 2000.
Tsang RW, Fyles AW, Milosevic M, Syed A, Pintilie M, Levin W, Manchul L.
Interrelationship of proliferation and hypoxia in carcinoma of the cervix.
Int J Radiat Oncol Biol Phys, 46: 95-99, 2000.
Fyles A, Milosevic M, Pintilie M, Syed A, Hill R.
Anemia, hypoxia and transfusion in patients with cervix cancer.
Radiother Oncol, 57:13-19, 2000.
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1999
Chiarotto and Hill, RP. A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor
(VEGF) mRNA in cervical cancer cell lines. Brit J
Cancer, 80:1518-1524, 1999.
Kavanagh M-C, Minkin S, Hill RP. The use of needle biopsies for radiobiological assessment of oxygen levels in
KHT-C tumours. Radia Res, 152: 107-112, 1999.
Kavanagh, M-C, Tsang, V., Chow, S., Koch, C., Hedley, D., Minkin, S., and Hill, RP.
A comparison in individual murine tumors of techniques for measuring oxygen levels.
Int J Radiat Oncol Bio
Phys, 44: 1137-1146,1999.
Tsang R, Fyles A, Li YQ, Rajaraman M, Chapman W, Pintilie M, Wong S.
Tumour proliferation and apoptosis in human uterine cervix carcinoma I: correlations between variables.
Radiother Oncol, 50: 85-92, 1999.
Tsang R, Wong CS, Fyles AW, Levin W, Manchul L, Milosevic M, Chapman W, Li YQ, Pintilie M.
Tumour proliferation and apoptosis in human uterine cervix carcinoma II: correlations with clinical outcome.
Radiother Oncol, 50: 93-101, 1999.
Milosevic M, Fyles AW, Hill, RP. The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysis.
Int J Radiat Oncol Biol Phys, 43:1111-1123, 1999.
Moreno-Merlo F, Nicklee T, Hedley DW.
Association between tissue hypoxia and elevated non-protein sulphydryl concentrations in human cervical carcinoma xenografts.
British Journal of Cancer, 81:
989-993, 1999.
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Pre-1999
De Jaeger K, Merlo FM, Kavanagh MC,
Fyles AW, Hedley D, Hill RP.
Heterogeneity of tumor oxygenation: relationship to tumor
necrosis, tumor size, and metastasis.
Int J Radiat Oncol Biol Phys, 42(4):717-721, 1998.
Fyles AW, Milosevic M, Pintilie M,
Hill RP.
Cervix cancer oxygenation measured following external radiation
therapy.
Int J Radiat Oncol Biol Phys, 42(4):751-753, 1998.
Fyles AW, Milosevic M, Wong R,
Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L,
Keane TJ, Hill RP.
Oxygenation predicts radiation response and survival in patients
with cervix cancer.
Radiother Oncol, 48(2):149-156, 1998.
Milosevic MF, Fyles AW, Wong R,
Pintilie M, Kavanagh MC, Levin W, Manchul L, Keane TJ, Hill RP.
Interstitial fluid pressure in cervical carcinoma: within tumor
heterogeneity, and relation to oxygen tension.
Cancer, 82(12):2418-2426, 1998.
Cuvier C, Jang A, Hill RP.
Exposure to hypoxia, glucose starvation and acidosis: effect on
invasive capacity of murine tumor cells and correlation with
cathepsin (L + B) secretion.
Clin Exp Metastasis, 15(1):19-25, 1997.
Jang A, Hill RP.
An examination of the effects of hypoxia, acidosis, and glucose
starvation on the expression of metastasis-associated genes in
murine tumor cells.
Clin Exp Metastasis, 15(5):469-483, 1997.
Wong RK, Fyles A, Milosevic M,
Pintilie M, Hill RP.
Heterogeneity of polarographic oxygen tension measurements in
cervix cancer: an evaluation of within and between tumor
variability, probe position, and track depth.
Int J Radiat Oncol Biol Phys, 39(2):405-412, 1997.
Kavanagh MC, Sun A, Hu Q, Hill RP.
Comparing techniques of measuring tumor hypoxia in different
murine tumors: Eppendorf pO2 Histograph, [3H]misonidazole
binding and paired survival assay. Radiat Res,
145(4):491-500, 1996.
Hu Q, Kavanagh MC, Newcombe D, Hill
RP.
Detection of hypoxic fractions in murine tumors by comet assay:
comparison with other techniques. Radiat Res,
144(3):266-275, 1995.
Schlappack OK, Zimmermann A, Hill
RP.
Glucose starvation and acidosis: effect on experimental
metastatic potential, DNA content and MTX resistance of murine
tumour cells. Br J Cancer, 64(4):663-670, 1991.
Hill RP.
Tumor progression: potential role of unstable genomic changes.
Cancer Metastasis Rev, 9(2):137-147, 1990.
Young SD, Hill RP.
Effects of reoxygenation on cells from hypoxic regions of solid
tumors: anticancer drug sensitivity and metastatic potential.
J Natl Cancer Inst, 82(5):371-380, 1990.
Young SD, Hill RP.
Effects of reoxygenation on cells from hypoxic regions of solid
tumors: analysis of transplanted murine tumors for evidence of
DNA overreplication.
Cancer Res, 50(16):5031-5038, 1990.
Young SD, Marshall RS, Hill RP.
Hypoxia induces DNA overreplication and enhances metastatic
potential of murine tumor cells.
Proc Natl Acad Sci U S A, 85(24):9533-9537, 1988.
Hill RP and Pallavicini MG.
Hypoxia and the radiation response of tumors. Adv Exp Med
Biol, 159:17-35, 1983.
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2003 | 2002 | 2001 |
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Pre-1999
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