Publications, by Research Area

Publications, by Topic

Herrera FG, Chan P, Doll C, Milosevic M, Oza A, Syed A, Pintilie M, Levin W, Manchul L, Fyles A. A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment. Int J Radiat Oncol Biol Phys, 67(1)97-103, 2007.

Fyles A, Milosevic M, Pintilie M, Syed A, Levin W, Manchul L, Hill RP. Long-term performance of interstitial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiother Oncol, 80(2):132-137, 2006.

Haider MA, Milosevic M, Fyles A, Sitartchouk I, Yeung I, Henderson E, Lockwood G, Lee TY, Roberts TP. Assessment of the tumour microenvironment in cervix cancer using dynamic contrast enhanced CT, interstitial fluid pressure and oxygen measurements. Int J Radiat Oncol Biol Phys, 62(4):1100-1107, 2005.

Hedley DW, Nicklee T, Moreno-Merlo F, Pintilie M, Fyles A, Milosevic M, Hill RP. Relations between non-protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinoma. Int J Radiat Oncol Biol Phys, 61(1):137-44, 2005.

Parker C, Milosevic M, Toi A, Sweet J, Panzarella T, Bristow R, Catton C, Catton P, Crook J, Gospodarowicz M, McLean M, Warde P, Hill RP. Polarographic electrode study of tumor oxygenation in clinically localized prostate cancer. Int J Radiat Oncol Biol Phys, 58(3):750-7, 2004.

Doll CM, Milosevic M, Pintilie M, Hill RP, Fyles AW. Estimating hypoxic status in human tumors: A simulation using Eppendorf oxygen probe data in cervical cancer patients. Int. J. Radiat. Oncol. Biol. Phys. 55(5):1239-1246, 2003.

Hedley D, Pintilie M, Woo J, Morrison A, Birle D, Fyles A, Milosevic M, Hill R. Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. Clin Cancer Res, 9(15):5666-74, 2003.

Haugland,H.K., Vukovic,V., Pintillie,M., Fyles,A.W., Milosevic,M., Hill,R.P., and Hedley,D.W. Expression of hypoxia-inducible factor 1a in cervical carcinomas: correlation with tumor oxygenation and clinical outcome. Int J Radiat Oncol Biol Phys 53: 854-861, 2002.

Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill R. Tumor hypoxia is an independent predictor of outcome in patients with node negative cervix cancer. J Clin Oncol, 20: 680-687, 2002.

Fyles A, Voduc D, Syed A, Milosevic M, Pintilie M, Hill R. The effect of smoking on tumour oxygenation and treatment outcome in cervical cancer. Clin. Oncol. 14: 443-446, 2002.

Pitson G, Fyles A, Milosevic M, Wylie J, Pintilie M, Hill R. Tumor size and oxygenation are independent predictors of nodal disease in patients with cervix cancer. International Journal of Radiation Oncol. Biol. Phys. 51: 699-703, 2001.

Milosevic M, Quirt I, Levin W, Fyles A, Chapman W. Intra-tumoral sickling in a patient with sickle trait and cervix cancer: implications for tumor oxygenation and outcome following therapy. Gyn Oncol, 83: 428-431, 2001.

Milosevic M, Fyles A, Pintilie M, Levin W, Manchul L, Hill R Interstitial Fluid Pressure Predicts Survival in Patients with Cervix Cancer Independent of Clinical Prognostic Factors and Tumor Oxygen Measurements. Cancer Res, 61:6400-5, 2001.

Tsang RW, Fyles AW, Milosevic M, Syed A, Pintilie M, Levin W, Manchul L. Interrelationship of proliferation and hypoxia in carcinoma of the cervix. Int J Radiat Oncol Biol Phys, 46: 95-99, 2000.

Fyles AW, Milosevic M, Pintilie M, Hill RP. Cervix cancer oxygenation measured following external radiation therapy. Int J Radiat Oncol Biol Phys, 42(4):751-753, 1998.

Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, Hill RP. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol, 48(2):149-156, 1998.

Wong RK, Fyles A, Milosevic M, Pintilie M, Hill RP. Heterogeneity of polarographic oxygen tension measurements in cervix cancer: an evaluation of within and between tumor variability, probe position, and track depth. Int J Radiat Oncol Biol Phys, 39(2):405-412, 1997.

top

Clinical-IFP

Khosravani H, Chugh B, Milosevic MF, Norwich KH. Time response of interstitial fluid pressure measurements in cervix cancer. Microvasc Res, 68(1):63-70, 2004.

Milosevic M, Fyles AW, Hill, RP. The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysis. Int J Radiat Oncol Biol Phys, 43:1111-1123, 1999.

Milosevic MF, Fyles AW, Wong R, Pintilie M, Kavanagh MC, Levin W, Manchul L, Keane TJ, Hill RP. Interstitial fluid pressure in cervical carcinoma: within tumor heterogeneity, and relation to oxygen tension. Cancer, 82(12):2418-2426, 1998.

top

Imaging

Haider MA, Sitartchouk I, Roberts TP, Fyles A, Hashmi AT, Milosevic M. Correlations between dynamic contrast-enhanced magnetic resonance imaging-derived measures of tumor microvasculature and interstitial fluid pressure in patients with cervical cancer. J Magn Reson Imaging, 25(1)153-159, 2007.

Henderson E, Milosevic M, Haider M, Yeung IW. Functional CT imaging of prostate cancer. Phys Med Biol, 48(18):3085-100, 2003.

top

Biomarkers

Schwock J, Ho JC, Luther E, Hedley DW, Geddie WR. Detection and measurement of phosphorylated signaling proteins in solid tumor fine-needle biopsies by laser-scanning cytometry. Diagnostic Molecular Pathology, (in press).

Pham NA, Morrison A, Schwock J, Aviel-Ronen S, Iakovlev V, Tsao MS, Ho J, Hedley DW. Quantitative image analysis of immunohistochemical stains using a CMYK color model. Diagn Pathol, 2:8, 2007.

Bachtiary B, Boutros PC, Pintilie M, Shi W, Bastianutto C, Li JH, Schwock J, Zhang W, Penn LZ, Jurisica I, Fyles A, Liu FF. Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin Cancer Res, 12(19)5632-5640, 2006.

Schwock J, Geddie WR, Hedley DW. Analysis of hypoxia-inducible factor-1alpha accumulation and cell cycle in geldanamycin-treated human cervical carcinoma cells by laser scanning cytometry. Cytometry A, 68(2):59-70, 2005.

Hedley D, Pintilie M, Woo J, Nicklee T, Morrison A, Birle D, Fyles A,
Milosevic M, Hill R. Up-regulation of the redox mediators thioredoxin and apurinic/apyrimidinic excision (APE)/Ref-1 in hypoxic microregions of invasive cervical carcinomas, mapped using multispectral, wide-field fluorescence image analysis. Am J Pathol, 164(2):557-65, 2004.

Maseide K, Kandel RA, Bell RS, Catton CN, O'Sullivan B, Wunder JS, Pintilie M, Hedley D, Hill RP. Carbonic anhydrase IX as a marker for poor prognosis in soft tissue sarcoma. Clin Cancer Res, 10(13):4464-71, 2004.

Ruoso P, Hedley DW. Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma. Cancer Chemother Pharmacol. 54(1):49-56, 2004.

Tsang RW, Juvet S, Pintilie M, Hill RP, Wong CS, Milosevic M, Chapman W, Levin W, Manchul LA, Fyles AW. Pretreatment proliferation parameters do not add predictive power to clinical factors in cervical cancer treated with definitive radiation therapy. Clin Cancer Res, 9(12):4387-95, 2003.

Vukovic,V., Nicklee,T., and Hedley,D.W. Multiparameter fluorescence mapping of non-protein sulfydryl status in relation to blood vessels and hypoxia in cervical carcinoma xenografts. Int J Radiat Oncol Biol Phys 52:837-43, 2002.

Constantinou, P., Vukovic, V., Haugland, H. K., Nicklee, T., Hedley, D. W., and Wilson, B. C. Imaging of whole tumor cut sections using a novel scanning beam confocal fluorescence MACROscope((R)). J Biomed Optics, 6: 326-331, 2001.

Vukovic, V., Haugland, H.K., Nicklee, T., Morrison, A.J., and Hedley, D.W. Hypoxia inducible factor-1a is an intrinsic marker for hypoxia in cervical cancer xenografts. Cancer Res 61:7394-7398, 2001.

Vukovic,V., Nicklee,T., and Hedley,D.W. Microregional heterogeneity of non-protein thiols in cervical carcinomas assessed by combined use of HPLC and fluorescence image analysis. Clin Cancer Res, 6:1826-1832, 2000.

Tsang R, Fyles A, Li YQ, Rajaraman M, Chapman W, Pintilie M, Wong S. Tumour proliferation and apoptosis in human uterine cervix carcinoma I: correlations between variables. Radiother Oncol, 50: 85-92, 1999.

Tsang R, Wong CS, Fyles AW, Levin W, Manchul L, Milosevic M, Chapman W, Li YQ, Pintilie M. Tumour proliferation and apoptosis in human uterine cervix carcinoma II: correlations with clinical outcome. Radiother Oncol, 50: 93-101, 1999.

top

pO2

Hedley D, Schwock J, Pham NA, Cao M. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo. Cancer Chemotherapy and Pharmacology, (in press).

Birle DC, Hedley DW. Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors. Cancer Res, 67(4)1735-1743, 2007.

Birle DC, Hedley DW. Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts. Mol Cancer Ther, 5(10)2494-2502, 2006.

Lolkema MP, Gervais ML, Snijckers CM, Hill RP, Giles RH, Voest EE, Ohh M. Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain. J Biol Chem, Apr 11, 2005.

Cairns RA, Hill RP. A fluorescent orthotopic model of metastatic cervical carcinoma. Clin Exp Metastasis, 21(3):275-81, 2004.

Cairns RA, Hill RP. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res, 64(6):2054-61, 2004.

Stickle NH, Chung J, Klco JM, Hill RP, Kaelin WG Jr, Ohh M. pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol, 24(8):3251-61, 2004.

Kalliomaki T, Hill RP. Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines. Br J Cancer, 90(9):1842-9, 2004.

Zhang L, Hill RP. Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res, 64(12):4180-9, 2004.

De Jaeger, K., Kavanagh, M-C., Hill, RP. Relationship of hypoxia to metastatic ability in rodent tumours. Brit J Cancer, 84: 1280-1285, 2001.

Cairns, RA, Kalliomaki T., Hill RP. Acute (cyclic) Hypoxia Enhances Spontaneous Metastasis of Murine Tumors. Cancer Res 61 (24): 8903-8, 2001.

Vukovic, V., Nicklee,T., and Hedley,D.W. Differential effects of buthionine sulphoximine in hypoxic and non-hypoxic regions of human cervical carcinoma xenografts. Radiother Oncol 60(1):69-73, 2001.

Chiarotto and Hill, RP. A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines. Brit J Cancer, 80:1518-1524, 1999.

Kavanagh M-C, Minkin S, Hill RP. The use of needle biopsies for radiobiological assessment of oxygen levels in KHT-C tumours. Radia Res, 152: 107-112, 1999.

Kavanagh, M-C, Tsang, V., Chow, S., Koch, C., Hedley, D., Minkin, S., and Hill, RP. A comparison in individual murine tumors of techniques for measuring oxygen levels. Int J Radiat Oncol Bio Phys, 44: 1137-1146,1999.

Moreno-Merlo F, Nicklee T, Hedley DW. Association between tissue hypoxia and elevated non-protein sulphydryl concentrations in human cervical carcinoma xenografts. British Journal of Cancer, 81: 989-993, 1999.

De Jaeger K, Merlo FM, Kavanagh MC, Fyles AW, Hedley D, Hill RP. Heterogeneity of tumor oxygenation: relationship to tumor necrosis, tumor size, and metastasis. Int J Radiat Oncol Biol Phys, 42(4):717-721, 1998.

Cuvier C, Jang A, Hill RP. Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clin Exp Metastasis, 15(1):19-25, 1997.

Jang A, Hill RP. An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin Exp Metastasis, 15(5):469-483, 1997.

Kavanagh MC, Sun A, Hu Q, Hill RP. Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, [3H]misonidazole binding and paired survival assay. Radiat Res, 145(4):491-500, 1996.

Hu Q, Kavanagh MC, Newcombe D, Hill RP. Detection of hypoxic fractions in murine tumors by comet assay: comparison with other techniques. Radiat Res, 144(3):266-275, 1995.

Schlappack OK, Zimmermann A, Hill RP. Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. Br J Cancer, 64(4):663-670, 1991.

Young SD, Hill RP. Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential. J Natl Cancer Inst, 82(5):371-380, 1990.

Young SD, Hill RP. Effects of reoxygenation on cells from hypoxic regions of solid tumors: analysis of transplanted murine tumors for evidence of DNA overreplication. Cancer Res, 50(16):5031-5038, 1990.

Young SD, Marshall RS, Hill RP. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A, 85(24):9533-9537, 1988.

Hill RP and Pallavicini MG. Hypoxia and the radiation response of tumors. Adv Exp Med Biol, 159:17-35, 1983.

top

IFP

Skliarenko JV, Lunt SJ, Gordon ML, Vitkin A, Milosevic M, Hill RP. Effects of the vascular disrupting agent ZD6126 on the interstitial fluid pressure and cell survival in tumors. Cancer Res, 66(4):2074-2080, 2006.

top

DNA Repair

Bristow RG, Ozcelik H, Jalali F, Chan N, Vesprini D. Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies. Radiotherapy and Oncology, (in press).

Chan N, Milosevic M, Bristow RG. Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies. Future Oncology, (in press).

Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM, Bristow RG. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol, 76(2):168-176, 2005.

Bindra RS, Schaffer PJ, Meng A, Woo J, Maseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Mol Cell Biol, 24(19):8504-18, 2004.

Vukovic V, Pheng SR, Stewart A, Vik CH, Hedley DW. Protection from radiation-induced DNA single strand breaks by induction of nuclear metallothionein. International Journal of Radiation Biology, 76:757-762, 2000.

top

Reviews

Bristow RG, Ozcelik H, Jalali F, Chan N, Vesprini D. Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies. Radiotherapy and Oncology, (in press).

Chan N, Milosevic M, Bristow RG. Tumor hypoxia, DNA repair and prostate cancer progression: new targets and new therapies. Future Oncology, (in press).

Milosevic M, Fyles A, Hedley D, Hill R. The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol, 14(3):249-58, 2004.

Subarsky P and Hill RP. Metastasis and the tumor microenvironment. Clin Exper Metastasis, 20(3):237-250, 2003.

Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med, 3(7):659-71, 2003.

Hill RP, Fyles W, Milosevic M, Pintilie M, Tsang RW. Is there a relationship between repopulation and hypoxia/reoxygenation? Results from human carcinoma of the cervix. Int J Radiat Biol, 79(7):487-94, 2003.

Milosevic M, Fyles A, Hill R. Interstitial fluid pressure in cervical cancer: guide to targeted therapy. Am J Clin Oncol. 24:516-21, 2001.

Hill RP. Tumour Metastasis Models. In: Cancer Handbook. Eds Nicolson G, Haier J, Nature Publishing Group, London 2001.

Hill RP, Cairns R, De Jaeger K, Jang A. pH, Hypoxia and Metastasis. In: Causes and Consequences of Acidic pH in tumours Novartis Symposium 240. Wiley, London 2001.

Fyles A, Milosevic M, Pintilie M, Syed A, Hill R. Anemia, hypoxia and transfusion in patients with cervix cancer. Radiother Oncol, 57:13-19, 2000.

Hill RP. Tumor progression: potential role of unstable genomic changes. Cancer Metastasis Rev, 9(2):137-147, 1990.

top

Last Updated: May 29, 2007