McEwen Monthly

June 2011 |

Join Stem Cell City!

June 15, 2011 marked the kick-off of Stem Cell City, an initiative by the McEwen Centre for Regenerative Medicine to inform the public about the latest discoveries in stem cell research and to allow people to articulate their support of using regenerative medicine to defeat the major diseases of our time.

UHN CEO Dr. Bob Bell addresses the audience at the launch of Stem Cell City.

McEwen Centre co-founders Cheryl and Rob McEwen announced the opening of this exciting project and encouraged everyone to join in their crusade to fight disease through the support of regenerative medicine. They were joined by McEwen Centre director Dr. Gordon Keller, Ontario Premier Dalton McGuinty and Minister of Citizenship and Education Dr. Eric Hoskins, UHN CEO Dr. Bob Bell, Robert Klein, Chairman of the Board of the California Institute for Regenerative Medicine (CIRM), and patient advocate, model, actor and stem cell transplant recipient Lisa Ray.

To become a citizen, and for more information, please visit

McEwen Centre Website Modernization

McEwen Centre WebsiteThe McEwen Centre website has undergone a major overhaul! The new website offers an interactive look into the research labs and facilities at the McEwen Centre, provides an overview of the research focus, details patient success stories and offers the opportunity to learn more about the ongoing research and activities through access to Stem Cell City. Be sure to check out all the changes at!

ISSCR: McEwen Centre Award for Innovation

Drs. Shinya Yamanaka and Kazutoshi TakahashiThe recipients of the inaugural McEwen Centre Award for Innovation are Drs. Kazutoshi Takahashi and Shinya Yamanaka, Center for iPS Cell Research and Application, Kyoto University, Japan.The award was given out at the 9th Annual ISSCR Conference in recognition of their paradigm-shifting work demonstrating the reprogramming of adult/tissue-specific cells using transcription factors.

Supported by the McEwen Centre, this award reconizes original thinking and groundbreaking research pertaining to stem cells or regenerative medicine that opens new avenues of exploration towards the understanding or treatment of human disease or affliction.

CCRM Launch

Centre for Commercialization of Regenerative MedicineThe Centre for Commercialization of Regenerative Medicine (CCRM) officially launched June 14, 2011. Led by Dr. Peter Zandstra, the vision of the CCRM is to move regenerative medicine (RM) from bench to bedside by supporting the development of technologies that reduce cost and increase efficiency of RM-based medicine. The CCRM will be a global hub for the commercialization of RM by engaging industry partners and attracting investment in Ontario.

CCRM core activities reside within three key product development and commercialization platforms: cell reprogramming, cell manufacturing and biomaterials and tissue mimetics. For more information, please visit the CCRM website.

Select Recent Publications

-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship. Arntfield ME, van der Kooy D. Bioessays. 2011 Jun 16. [Abstract]

A series of systematic reviews on the treatment of acute spinal cord injury: A foundation for best medical practice. Fehlings M, Cadotte DW, Fehlings LN. J Neurotrauma. 2011 Jun 8. [Abstract]

Myxopapillary ependymoma: correlation of clinical and imaging features with surgical resectability in a series with long-term follow-up. Al-Habib A, Al-Radi OO, Shannon P, Al-Ahmadi H, Petrenko Y, Fehlings MG. Spinal Cord. 2011 Jun 7. [Abstract]

Identification of a role for the nuclear receptor EAR-2 in the maintenance of clonogenic status within the leukemia cell hierarchy. Ichim CV, Atkins HL, Iscove NN, Wells RA. Leukemia. 2011 Jun 3. [Abstract]

Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization. Rowland JW, Lee JJ, Salewski RP, Eftekharpour E, van der Kooy D, Fehlings MG. Stem Cells Dev. 2011 May 23. [Abstract]

Endothelial cells guided by immobilized gradients of vascular endothelial growth factor on porous collagen scaffolds. Odedra D, Chiu LL, Shoichet M, Radisic M. Acta Biomater. 2011 May 10. [Abstract]

Endobronchial ultrasound-guided transbronchial needle aspiration in the management of previously treated lung cancer. Anraku M, Pierre AF, Nakajima T, de Perrot M, Darling GE, Waddell TK, Keshavjee S, Yasufuku K. Ann Thorac Surg. 2011 May 16. [Abstract]

Cardiovascular outcomes are predicted by exercise-stress myocardial perfusion imaging: Impact on death, myocardial infarction, and coronary revascularization procedures. Lee DS, Verocai F, Husain M, Al Khdair D, Wang X, Freeman M, Iwanochko RM. Am Heart J. 2011 May. [Abstract]

Local long-term expression of lentivirally delivered IL-10 in the lung attenuates obliteration of intrapulmonary allograft airways. Hirayama S, Sato M, Loisel-Meyer S, Liu M, Yeung JC, Wagnetz D, Cypel M, Zehong G, Medin JA, Keshavjee S. Hum Gene Ther. 2011 May 13. [Abstract]

The Graded Redefined Assessment of Strength Sensibility and Prehension (GRASSP) - reliability and validity. Kalsi-Ryan S, Beaton D, Curt A, Duff S, Popovic M, Rudhe C, Fehlings M, Verrier M. J Neurotrauma. 2011 May 13. [Abstract]

The primary benefits of Angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy. Martino TA, Tata N, Simpson JA, Vanderlaan R, Dawood F, Kabir MG, Khaper N, Cifelli C, Podobed P, Liu PP, Husain M, Heximer S, Backx PH, Sole MJ. J Am Coll Cardiol. 2011 May 17. [Abstract]