Research at University Health Network
 
Technology Transfer
Menu Level 3  
   
 
Anthony E Lang, OC, MD, FRCPC, FAAN, FCAHS, FRSC
Keywords: clinical trials, Parkinson's disease, movement disorders, neuropharmacology 

Research Interests
Solving the 'Parkinson Puzzle'

Our clinical research is conducted in the Morton and Gloria Shulman Movement Disorders Clinic and with important support through the Edmond J. Safra Program in Parkinsons Disease and recently the Lily Safra Chair in Movement Disorders.

We are involved in a large number of clinical research trials including pharmacologic studies evaluating a number of drugs at various stages of Parkinson's disease. Several of these trials are in collaboration with the Parkinson Study Group.

The Toronto Western Hospital Movement Disorders Program remains a world leader in the surgical management of Parkinson's disease. Recent studies include evaluation of deep brain stimulation in novel sites or for new indications.

Collaborators in the surgical arm of the program include Drs. Alfonso Fasano and Renato Munhoz in neurology and Drs. Andres Lozano, Moji Hodaie, Suneil Kalia and Bill Hutchison in neurosurgery.

Neuropsychological and imaging evaluations of patients participating in these studies represent an important component of our collaborative research. Additional neurophysiologic studies in surgical patients as well as in other movement disorders are carried out by Dr. Robert Chen.

Clinical trials are very active in the program. Dr. Susan Fox directs a program in clinical neuropharmacology and early proof of principle studies. Dr. Connie Marras has a PhD in clinical epidemiology and is directing a program in this field as it applies to movement disorders.

Neuroimaging is an important component of our program and in addition to magnetic resonance imaging we are actively developing a positron-emission tomography program. Dr. Antonio Strafella directs a very active functional imaging research program using positron emission tomography and fMRI.

Molecular and cell biology and clinical genetics of movement disorders including Parkinson's disease is an areas of expanding interest in collaboration with Drs. Peter St George-Hyslop, Ekaterina Rogaeva and Lorraine Kalia and we continue active work in the field of neuropathology in collaboration with the division of neuropathology at UHN and Dr. Lili-Naz Hazrati.

Finally, we are actively collaborating with Dr. Jonathan Brotchie's laboratory in the study of animal models of movement disorders, particularly levodopa-induced dyskinesias.

This broad based research program is directed at attempting to solve the 'Parkinson puzzle' at many levels including attempts at understanding the cause(s), improving the accuracy of diagnosis preventing/slowing the progression and treating the later stages more effectively.

In addition to the Lily Safra Chair at the hospital, Dr. Lang holds the Jack Clark Chair at the University of Toronto Centre for Research in Neurodegenerative Disease (CRND). This support has expanded our research program considerably with greater ties to basic research efforts (e.g., the development of the Parkinson's disease laboratory under the direction of Dr. Anurag Tandon), allowing a more seamless connection between the bench and the bedside (i.e., molecules to populations). In 2013, the CRND moved to the TWH site and this has placed us in a unique position to explore new opportunities in translational research in Parkinsons disease and related neurodegenerative disorders.

Pubmed Publications
Perform an automatic PubMed search of this researcher's publications.
 
 
 
  Anthony E Lang, OC, MD, FRCPC, FAAN, FCAHS, FRSC
Mailing Address
Primary Office
Toronto Western Hospital
McLaughlin Pavilion
7th Floor Room 7-403
399 Bathurst St.
Toronto, Ontario
Canada M5T 2S8

 
Email

Phone Numbers
416-603-6422(Primary)
416-603-5004(FAX)
416-603-5112(LAB)
416-603-5875(Additional)
416.603.5800 x3141(Additional)

 
Faculty
Robert Chen  
Alfonso Fasano  
Susan Fox  
Lorraine Kalia 
Connie Marras  
Renato Munhoz  
Antonio Strafella  
Trainees
Camilia de Acquino  
Isabelle Beaulieu Boire  
Veronica Bruno  
Amaal Dakheel  
Drew Kern  
Tiago Mestre  
Elizabeth Snow  
Carmen Gasca-Salas  

   
 
 
 
Home Researchers Facilities Support Services Programs Commercialization Ethics News About UHN Institutes OCI Techna TGRI TRI TWRI