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Marc de Perrot

Scientist
Division of Experimental Therapeutics - Respiratory & Critical Care
Toronto General Research Institute (TGRI)

Clinical Studies Resource Centre Member
Ontario Cancer Institute

Keywords: immunotherapy, clinical trials, lung transplantation, extrapleural pneumonectomy, pulmonary endarterectomy, ischemia-reperfusion injury 

Research Interests
Chemo-immunotherapy
The overall goal is to improve the outcome of mesothelioma by combining conventional chemotherapy with immunotherapy in murine mesothelioma models.

Although the first line chemotherapy composed of cisplatin and Pemetrexed (Alimta) could prolong survival compared with cisplatin alone, the effect is limited. One neglected issue that has been highlighted is cancer cell repopulation during the intervals of chemotherapy. Evidence has shown that the rate of repopulation of surviving cancer cells accelerates over time. Therefore, novel approaches inhibiting this process need to be developed. The immune suppression is quite common in cancer microenvironment including mesothelioma. We attempt to improve the efficacy of chemotherapy by removing the brake of immunosuppression so as to enhance specific anti-tumor immunity. The immunosuppressive compartments such as regulatory T cells (Treg), CTLA-4, PD-1 and so on can be employed as targets to enhance T cell immune response.

We have demonstrated that Treg cell depletion between cycles of chemotherapy has resulted in improvement of the anti-tumor effect. CTLA-4 blockade expands infiltrating T cells and inhibits cancer cell repopulation between chemotherapy treatments in murine mesothelioma models.

Pubmed Publications
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  Marc de Perrot
Mailing Address
Primary Office
MaRS Centre
Toronto Medical Discovery Tower
2nd Floor Room 2-817
101 College St.
Toronto, Ontario
Canada M5G 1L7

Primary Office
Toronto General Hospital
Norman Urquhart
9th Floor Room 9NU961
200 Elizabeth St.
Toronto, Ontario
Canada M5G 2C4

Primary Office
MaRS Centre
Toronto Medical Discovery Tower
2nd Floor Room 2-501
101 College St.
Toronto, Ontario
Canada M5G 1L7

 
Email

Phone Numbers
416-581-7507(Primary)
416-340-3478(FAX)
416-581-7639(LAB)
416-340-5549(Primary)
416-790-9433(Pager)

 
Staff and Trainees
Luis De la Maza
Yidan Zhao
Licun Wu
Zhihong (Hana) Yun
Ivone Ornelas

   
 
 
 
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