RaySearch Licenses Groundbreaking Technology from Princess Margaret Hospital

STOCKHOLM, MARCH 7, 2011 - RaySearch Laboratories AB (publ.) has entered into an exclusive license agreement with Princess Margaret Hospital (PMH) in Toronto, Canada regarding deformable image registration technology.  RaySearch and PMH have a long-standing research collaboration focused on strategies and tools for adaptive radiation therapy. The new agreement, licensed through the Technology Development and Commercialization Office at University Health Network, further deepens the relationship and gives RaySearch the right to integrate algorithms and know-how from PMH’s research software Morfeus into RaySearch’s RayStation® treatment planning system.

Morfeus contains a set of algorithms for deformable image registration based on biomechanical
modeling of anatomical structures. This makes it possible to track how the radiation dose is delivered
to the patient taking into account changes occurring in the patient’s anatomy over the course of
treatment. This information can be used to further refine the treatment which has the potential to
increase tumor control as well as reduce the risk for side effects.

'“PMH is a world leader in adaptive radiation therapy and we are very excited that they have chosen to
work with us to commercialize this technology. The integration of algorithms that have been
thoroughly validated by the outstanding clinical experts at PMH further strengthens RayStation’s
position as the leading system for advanced treatment planning applications,” says Johan Löf, CEO of
RaySearch.

"Morfeus incorporates the true biomechanical nature of soft tissue deformation to improve accuracy
and extensibility. I am excited to partner with the RaySearch team to translate Morfeus technology into
the clinic," says Kristy Brock, Physicist at PMH and developer of Morfeus.”

The advanced biomechanical modeling in Morfeus incorporates not only the material properties of
various anatomical structures, but also how they interact and affect each other. Examples include the
sliding interface between the lung and the chest, and structural impact of bronchial tree in the lungs.
The PMH team has developed Morfeus over the last seven years, and they have thoroughly validated
the accuracy of the algorithms along the way. This is a painstaking process carried out by clinical
experts manually checking that the calculated position of different anatomical points actually matches
reality for a large amount of patients. The development and extensive validation of Morfeus has been
documented in several publications in renowned scientific journals. This know-how will now be
incorporated in RaySearch’s proprietary adaptive tools and a first version is expected to be released
later in 2011 as a part of RaySearch’s treatment planning system RayStation®.

“Raysearch has proven themselves through integration of physics and engineering principles into stateof-the-art clinical products for radiation therapy. This is another great example of them identifying
the best methods and working in partnership to advance them to the clinic for the benefit of cancer
patients all over the world.” says David Jaffray, Director of Radiation Physics at PMH.

RayStation® integrates all RaySearch’s advanced treatment planning solutions into a flexible treatment
planning system. It combines unique features such as multi-criteria optimization tools with full
support for 4D adaptive radiation therapy. It also includes functionality such as RaySearch’s marketleading algorithms for IMRT and VMAT optimization and highly accurate dose engines for both
photon and proton therapy. The system is built on the latest software architecture and has a graphical
user interface offering state-of-the-art usability.