Division of Genetics & Development
Toronto Western Research Institute (TWRI)
Keywords: regeneration, stem cells, spinal cord injury, neurotrophic factors |
Acute Spinal Cord and Brain Injury: In the Clinical Setting and in the Experimental Laboratory
The clinical research involves studies of acute management of traumatic spinal cord injury, ischemic lesions and demyelinating lesions and brain injuries especially the concussion spectrum of disorders. I am a principal investigator in the Christopher Reeve Foundation program ''North American Clinical Trial Network.'' NACTN is investigating new clinical treatments for patients with spinal cord injury, and I am a member of this organization's consortium and board.
I am the Project Director of the Canadian Sports Concussion Project at the Krembil Neuroscience Centre, Toronto Western Hospital. The Canadian Sports Concussion Project is conducting several research studies on concussion disorders, funded by the Ontario Brain Institute.
New treatment methods are being examined as part of national and international clinical trials. My studies also involve the epidemiology of sports and recreational injuries to the brain and spine, and research into the effectiveness of injury prevention programs. These are performed as part of ThinkFirst, Canada, and now Parachute Canada.
In the field of experimental spinal cord injury, I have developed several models of acute compression injury of the spinal cord and several quantifiable outcome measures. Various blood flow and angiographic techniques have been used to study post-traumatic ischemia.
I have examined the endogenous and transplanted stem/progenitor cells in the spinal cord. A variety of neurotrophic factors and other agents have been examined in rodent spinal cord injury.
We have studied the survival, migration and differentiation of endogenous and transplanted adult rat spinal cord ependymal region stem/progenitor cells generated in vitro from neurospheres. We have shown the effects of transplantation of these cells in the adult rodent spinal cord. We are also examining a number of bioengineering strategies involving guidance channels and drug delivery systems for axonal regeneration.
Recently, we have accomplished the culturing and transplantation of human adult spinal cord derived stem cells into rats with spinal cord injury.
- Part of the Krembil Neuroscience Centre
- Canadian Paraplegic Association Spinal Cord Injury Research Laboratory
- SCINET Group (CIHR)
- Section Editor, Journal of Neurotrauma
- Tator CH, Hashimoto R, Raich A, Norvell D, Fehlings MG, Harrop JS, Guest J, Aarabi B, Grossman RG. Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury. J Neurosurg Spine. 17(1 Suppl): 157-229, 2012.
- Mothe AJ, Zahir T, Santaguida C, Cook D, Tator CH. Neural stem/progenitor cells from the adult human spinal cord are multipotent and self-renewing and differentiate after transplantation. PLoS One. 6(11):e27079, 2011.
- Kang CE, Baumann MD, Tator CH, Shoichet MS. Localized and sustained delivery of fibroblast growth factor-2 from a nanoparticle-hydrogel composite for treatment of spinal cord injury. Cells Tissues Organs. 197:55-63, 2013
- Tator CH. Sport concussion education and prevention. Journal of Clinical Sport Psychology, 6:293-301, 2012.
- Nomura H, Kim H, Mothe A, Zahir T, Kulbatski I, Morshead CM, Shoichet MS, Tator CH. Endogenous radial glial cells support regenerating axons after spinal cord transection. Neuroreport. 21(13):871-6, 2010.
Laboratory and Research Photographs
Toronto Western Hospital
Krembil Discovery Tower
7th Floor Rm 7KD430
60 Leonard St.
Canada M5T 2S8
|Rita Van Bendegem|
|Xin Yan (Susan) Fan|