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Ontario Cancer Institute Toronto General Research Institute Toronto Rehabilitation Institute Toronto Western Research Institute
  • Located at the Princess Margaret Cancer Centre, Toronto, Ontario
  • Research foci: cancer— genomics, informatics, molecular biology, clinical trials, signalling pathways, structural biology and biophysics.
  • 361 scientists and clinician-scientists
  • $162M external funding
  • more
  • Located at the Toronto General Hospital, Toronto, Ontario
  • Research foci: cardiology, transplantation, immunology and infectious disease
  • 230 scientists and clinician-scientists
  • $73M external funding
  • more
  • Located at Toronto Rehab, Toronto, Ontario
  • Research foci: rehabilitation sciences, cardiopulmonary fitness and mobility
  • 119 scientists and clinician-scientists
  • $8M external funding
  • more
  • Located at the Toronto Western Hospital, Toronto, Ontario
  • Research foci: Neural and visual sciences, musculoskeletal disease and community and population health
  • 159 scientists and clinician-scientists
  • $35M external funding
  • more
 

 


A New Way to Decipher how Cancer Starts
Sep 15, 2014

Cancers arise due to spontaneous changes in DNA, which accumulate over time and cause unrestricted cell growth. The accumulation of these changes makes it challenging to ascertain which errors initiated the cancer.

To bypass this problem, researchers normally introduce DNA errors into cells and use the cells as a tool to identify cancer-causing genes. Unfortunately, this strategy has only been successfully achieved using cells from zebrafish and mice.

PM Senior Scientist Dr. Rama Khokha and her team have now resolved this issue using several cutting-edge genomic techniques and successfully introduced traceable genome-wide DNA errors into normal human cells.


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Cancer: UHN Researchers Awarded $6.6 Million
Sep 12, 2014

The Terry Fox Foundation has awarded $6.6 million to a team of researchers led by Drs. Bradly Wouters and Robert Bristow, both Senior Scientists at Princess Margaret (PM) Cancer Centre. These funds will support research to develop new and more personalized treatments that target the low oxygen levels in tumours—a characteristic that may contribute to cancer’s ability to resist treatment and spread within a person.


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Chemical Biology: A New Tool to Study the Role of SETD7 Protein
Sep 10, 2014

The protein SETD7 is found in different types of cells and is implicated in many physiological processes including metabolism and inflammation. Researchers believe that SETD7 influences these processes by adding specific chemical tags known as methyl groups to other proteins. However, how this activity contributes to the normal functioning of  cells is not fully understood by researchers, nor what role the  disruption of SETD7 activity plays in disease.

A team lead by Dr. Cheryl Arrowsmith, a Senior Scientist at PM Cancer Centre, in partnership with Pfizer, has synthesized a new chemical compound intended for use by other researchers to shed further light on the biological role of SETD7.


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