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Ontario Cancer Institute Toronto General Research Institute Toronto Rehabilitation Institute Toronto Western Research Institute
  • Located at the Princess Margaret Cancer Centre, Toronto, Ontario
  • Research foci: cancer— genomics, informatics, molecular biology, clinical trials, signalling pathways, structural biology and biophysics.
  • 361 scientists and clinician-scientists
  • $162M external funding
  • more
  • Located at the Toronto General Hospital, Toronto, Ontario
  • Research foci: cardiology, transplantation, immunology and infectious disease
  • 230 scientists and clinician-scientists
  • $73M external funding
  • more
  • Located at Toronto Rehab, Toronto, Ontario
  • Research foci: rehabilitation sciences, cardiopulmonary fitness and mobility
  • 119 scientists and clinician-scientists
  • $8M external funding
  • more
  • Located at the Toronto Western Hospital, Toronto, Ontario
  • Research foci: Neural and visual sciences, musculoskeletal disease and community and population health
  • 159 scientists and clinician-scientists
  • $35M external funding
  • more


Liver Disease: Despite Treatment Patients Not Protected From Liver Cancer
Sep 19, 2014

Chronic hepatitis B virus (HBV) infections often cause advanced liver disease (cirrhosis), which then develops into liver cancer.  Fortunately, treatment with the antiviral drug  entecavir (ETV), suppresses HBV infection in most patients. ETV therapy has also been associated with a decreased risk of developing liver cancer in HBV-infected Asian patients. However, it is still unclear if antiviral therapy has a similar effect on Caucasians since few long-term studies have carefully examined liver cancer incidence in Caucasian patients receiving ETV treatment.

A new study led by TGRI Senior Scientist Dr. Harry Janssen sought to answer this question by  following an ethnically diverse group of HBV-infected patients being treated at eleven European health centres.

Full Story

The ORT Times September Issue Now Available
Sep 17, 2014

Welcome to The ORT Times!

The UHN Office of Research Trainees (ORT) is proud to announce the September 2014 issue of The ORT Times! The ORT Times is a monthly e-newsletter focused on UHN trainees featuring news and editorials about trainee life, articles to help developing researchers get the most out of their training experience at UHN, and tips on career development.
Highlights from the September issue:

  • Lead Article: You are more marketable than you realize
  • ORT News: A unique website for research trainees
  • Awardees: The OSOTF/UNILEVER 2014-15 Award
  • Latest & Greatest: A. Yadollahi, F. Rudzicz, S. Mahallati, M. Coimbra, T.D. Bradle. Acoustic Estimation of Neck Fluid Volume. Annals of Biomedical Engineering. 2014 Oct;42(10):2132-2142
  • Travel Reports: Learn what's new in the fields of transplantation, gait and posture research, and the future of human brain mapping

Read the full September 2014 issue now!

Be sure to also take 120 seconds to complete this survey to help us learn more about what interests you in The ORT Times!

For any questions or comments about The ORT Times, please contact Priscilla DeLuca at

Dr. Linda Penn
Director, UHN Office of Research Trainees (ORT)
Senior Scientist, Princess Margaret Cancer Centre

Full Story

A New Way to Decipher how Cancer Starts
Sep 15, 2014

Cancers arise due to spontaneous changes in DNA, which accumulate over time and cause unrestricted cell growth. The accumulation of these changes makes it challenging to ascertain which errors initiated the cancer.

To bypass this problem, researchers normally introduce DNA errors into cells and use the cells as a tool to identify cancer-causing genes. Unfortunately, this strategy has only been successfully achieved using cells from zebrafish and mice.

PM Senior Scientist Dr. Rama Khokha and her team have now resolved this issue using several cutting-edge genomic techniques and successfully introduced traceable genome-wide DNA errors into normal human cells.

Full Story


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